A novel matrix of neural stem cells and a biodegradable polymer can quickly repair brain damage from stroke in rats. Within just seven days of injecting the concoction directly into the damaged part of the brain, new nerve tissue grew to fill stroke-induced cavities.
Scientists say that the key to the advance, published today in the journal Biomaterials, is the use of a biodegradable polymer called PLGA, which ensures that the stem cells remain in the area of stroke damage and establish connections with surrounding brain tissue. By reducing the number of stray stem cells, the system is likely to be safer as well as more effective than other methods, the researchers add.
Strokes, which occur due to bleeds or blocked blood vessels in the brain, cause some brain tissue to die. This dead tissue is then removed by the immune system, leaving a hole. “We would expect to see a much better improvement in the outcome after a stroke if we can fully replace the lost brain tissue, and that is what we have been able to do with our technique,” says Mike Modo, a neurobiologist at the Institute of Psychiatry at King’s College London, who oversaw the research.