Technut News

In 2006, Sinclair and National Institute on Aging gerontologist Rafael de Cabo, also a co-author of the Cell Metabolism study, used resveratrol to improve the health and extend the lives of obese mice on high-calorie diets. The latest study involved both obese and normal mice, fed standard, low- and high-calorie fare.

Regardless of mouse weight and diet, resveratrol worked wonders. At two years of age, or the mouse equivalent of senescence, the mice were more coordinated than their non-dosed counterparts. Their bones were thicker and stronger, their eyes free of cataracts, their hearts beating strong. At the cellular level, tissues displayed gene-level changes almost identical to those produced by caloric restriction.

The mitochondria of resveratrol-taking mice also proved healthy. Mitochondrial degeneration has been implicated in a variety of diseases, leading some researchers to believe that heart disease, cancer and dementia — all the so-called diseases of aging — have a common root.

source

I can’t believe what’s possible in mice these days.

I’ve seen’em heal from spinal paralysis, get a cure for sickle cell anemia, and more. And now they’re getting longer and healthier life in which they’re allowed to eat all they want.

Makes me wish I was one of them.

Double Your Lifespan with a Drug that Mutates Your Ribosomes

It’s been known for a while that restricting your diet will increase your lifespan, but now researchers have shown one reason why: Eating less causes your ribosomes (your cells’ protein factories) to mutate. And it’s looking like mutated ribosomes (pictured here) could be one key to life extension. The good news is that you may not have to starve yourself to mutate your ribosomes anymore. Biologists at the University of Washington have managed to induce the life-extending mutation in ribosomes with a drug that doubles the lifespan of yeast cells.

Geneticists Discover a Way to Extend Lifespans to 800 Years

There is now a way to extend the lifespan of organisms so that humans could conceivably live to be 800 years old. In an amazing development, scientists at the University of Southern California have announced that they’ve extended the lifespan of yeast bacteria tenfold — and the recipe they used to do it might easily translate into humans. It involves tinkering with two genes, and cutting down your calorie intake. Tests have already started on people in Ecuador.

Anti-Aging Drugs Could Change the Nature of Death

A new class of drugs aimed at age-related physical and mental deterioration could change not only the nature of life, but of death.

The drugs target mitochondria, the cellular power generators that provide our bodies with chemical energy. Over time, mitochondria accumulate damage, causing cells and eventually tissues to malfunction and break down. Some scientists believe that such seemingly disparate diseases as cancer, Parkinson’s, Alzheimer’s, diabetes and heart disease — all of which become more common with age — share a mitochondrial root. Fix the mitochondria, and you might fix aging itself.

Preliminary research suggests that mitochondria-rejuvenating drugs are capable, at least in lab animals, of halting these diseases and extending longevity. The research also suggests that, once they’ve reached the end of their traditional lifespans, these animals tend to die quickly and inexplicably, without any indication of disease or systemic breakdown.If the pattern holds in people, death would not be preceded by months or years of suffering. It would also come without warning, forever catching family and loved ones by surprise.

Aging Gracefully Requires Taking Out The Trash

Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration. In an upcoming issue of Autophagy, scientists at the Salk Institute for Biological Studies report for the first time that the opposite is true as well: Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity.

“We discovered that levels of several key pathway members are reduced in Drosophila neural tissue as a normal part of aging,” says senior author Kim Finley, Ph.D., a scientist in the Cellular Neurobiology Laboratory, “which suggests there is an age-dependent suppression of autophagy that may be a contributing factor for human neurodegenerative disorders like Alzheimer’s disease.”

Can We Cure Aging?

Jim Hammond is an elite athlete. He works out two hours a day with a trainer, pushing himself through sprints, runs, and strength-building exercises. His resting heart rate is below 50. He’s won three gold medals and one silver in amateur competitions this year alone, running races from 100 to 800 meters. In his division, he’s broken four national racing records. But perhaps the most elite thing about Hammond is his age.

He is 93. And really, there’s nothing much wrong with him, aside from the fact that he doesn’t see very well. He takes no drugs and has no complaints, although his hair long ago turned white and his skin is no longer taut.

His secret? He doesn’t have one. Hammond never took exceptional measures during his long life to preserve his health. He did not exercise regularly until his fifties and didn’t get serious about it until his eighties, when he began training for the Georgia Golden Olympics. “I love nothing better than winning,” he says. “It’s been a wonderful thing for me.” Hammond is aging, certainly, but somehow he isn’t getting old—at least, not in the way we usually think about it.

They say aging is one of the only certain things in life. But it turns out they were wrong. In recent years, gerontologists have overturned much of the conventional wisdom about getting old. Aging is not the simple result of the passage of time. According to a provocative new view, it is actually something our own bodies create, a side effect of the essential inflammatory system that protects us against infectious disease. As we fight off invaders, we inflict massive collateral damage on ourselves, poisoning our own organs and breaking down our own tissues. We are our own worst enemy.

…

Some ways to reduce inflammation are elementary. It is impossible to know exactly what is going on in Jim Hammond’s body, but all the aspects of his regimen—healthy food, exercise, and a good attitude—reduce systemic inflammation. Those of us without his tenacity can turn to drug companies, which are exploring new anti-inflammatory drugs like flavonoids. Researchers are also looking at new uses for old drugs—trying to prevent Alzheimer’s using ibuprofen, for example. “The research is really to prevent the chronic debilitating diseases of aging,” says Nir Barzilai, a molecular geneticist and director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York. “But if I develop a drug, it will have a side effect, which is that you will live longer.”

Point in case: aging is caused by molecular mechanisms in our bodies. Mechanisms that we can understand and manipulate in the coming biotech revolution.

The ‘elixir of life’ that could soon be given by injection

The prospect of holding back the years with a simple injection could be closer than we think.Scientists have taken a step towards developing a treatment that could erase the health problems associated with ageing.

While their breakthrough relates to rogue genes behind two rare genetic diseases, the approach they used could one day be harnessed to slow down the ageing process - creating an “elixir of life”.

The research focuses on mitochondria, sausage-shaped “powerhouses” in every cell of the body except red blood cells.

They turn the food we eat into energy that can be used by the heart, muscles, brain and other parts of the body.Research has suggested their deterioration is an important cause of ageing, according to a report in New Scientist magazine.

Defects in this mitochondrial DNA are blamed for a range of rare genetic diseases, including some forms of diabetes, blindness and heart problems.

They have also been linked to ageing - suggesting that fixing the flaws could slow down the onset of old age.

However, all attempts to fix flaws by inserting healthy DNA into mitochondria - a technique known as gene therapy - have failed, with the fresh genes stubbornly staying outside the powerhouses.

Now, by labelling the functional genes with an “address code” - which effectively tells them where to go - French scientists have succeeded in smuggling them inside the mitochondria.

Once there, the pair of genes repaired the damage behind a rare form of blindness and a muscle wasting disease, says the New Scientist report.

In time, the same approach could be used to create injections of genes that will erase flaws thought to be linked to the ageing process.

Longevity Pill Tested in Humans

Sirtris Pharmaceuticals announces that its souped-up version of resveratrol has passed early tests in humans.What if I told you there was a pill that slows aging and allows you to live a healthy life to age 100?

Such a pill may exist right now. It’s being tested in people in very early-stage human clinical trials. Today, the company making the pill, Sirtris Pharmaceuticals, announced its findings from preclinical testing in cells and animals, and also from tests conducted on 85 male volunteers this summer.

The verdict: so far, the pill works, although it will be years before we know how well it works, or if it can actually extend the life span of people in the same way that it has bumped up the life span of mice.

Below a documentary of Aubrey de Grey, the man who’s going to make humans immortal.

Not everybody can mentally ‘take’ the idea of living forever.

That’s why Aubrey has opponents.

(mainly old people who won’t live long enough to see it)

They attack him with meaningful and well thought-out arguments that really address the actual content of Aubrey’s ideas, such as:

• Aubrey is an angry individual

• Aubrey has only 3 laboratories doing his research

• Aubrey is very naïve and can’t possibly contribute to biology because he’s originally a computer scientist

• Aubrey doesn’t have any children so he wants to attain immortality himself through science

You think I’m making this shit up?

Enjoy the video.

A controversial biologist at Harvard claims he can extend life span and treat diseases of aging. He just may be right.

David Sinclair is very good at persuading people. The catch, says a longtime colleague and scientific rival, is that he is sometimes overly optimistic about his results. “David is brilliant, but sometimes he is too passionate and impatient for a scientist,” says another colleague. “So far, he is fortunate that his claims have turned out to be mostly true.”Sinclair’s basic claim is simple, if seemingly improb­able: he has found an elixir of youth. In his Australian drawl, the 38-year-old Harvard University professor of pathology explains how he discovered that resveratrol, a chemical found in red wine, extends life span in mice by up to 24 percent and in other animals, including flies and worms, by as much as 59 percent. Sinclair hopes that resveratrol will bump up the life span of people, too. “The system at work in the mice and other organisms is evolutionarily very old, so I suspect that what works in mice will work in humans,” he says.