Category Archives: aging / life extension

How Would You Like To Live Forever?

If you think it’s important to cure aging, now would be your chance to act.

A few minutes of your time is all it takes to become a small part of a big solution.

Undergrads Fighting Age Related Disease

From the webpage:

The Methuselah Foundation needs your help. We are supporting a project named “Undergrads Fighting Age Related Disease” (http://www.membersproject.com/project/view/BVVE2C), which has been submitted as part of the Amex Members Project initiative. The Methuselah Foundation has been nominated to complete this initiative and, if enough votes are obtained, could receive a grant of up to $1.5M from American Express towards the project’s completion.

It is free to vote and should only take you a few minutes. We need to get more than 2000 votes in the next 2 weeks (by Sept 1, 2008), so please support our cause and vote now.

Here are the instructions:

1. Go to this website:  http://www.membersproject.com/project/view/BVVE2C

2. Log in either as an Amex Card Member or as a Guest Member on the top right side (any US resident can vote)

3. Complete the Registration Form, which will give you your login ID

4. Click the Nominate button at:
http://www.membersproject.com/project/view/BVVE2C and post a supportive comment

Your action or inaction can make the 1.5 million dollar difference here.

If you love your life and want to hold on to it perpetually… vote!

Scientists stop the ageing process

Scientists have stopped the ageing process in an entire organ for the first time, a study released today says.

Published in today’s online edition of Nature Medicine, researchers at the Albert Einstein College of Medicine at Yeshiva University in New York City also say the older organs function as well as they did when the host animal was younger.

The researchers, led by Associate Professor Ana Maria Cuervo, blocked the ageing process in mice livers by stopping the build-up of harmful proteins inside the organ’s cells.

As people age their cells become less efficient at getting rid of damaged protein resulting in a build-up of toxic material that is especially pronounced in Alzheimer’s, Parkinson’s and other neurodegenerative disorders.

The researchers say the findings suggest that therapies for boosting protein clearance might help stave off some of the declines in function that accompanies old age.

In experiments, livers in genetically modified mice 22 to 26 months old, the equivalent of octogenarians in human years, cleaned blood as efficiently as those in animals a quarter their age.

By contrast, the livers of normal mice in a control group began to fail.

The benefits of restoring the cleaning mechanisms found inside all cells could extend far beyond a single organ, says Cuervo.

“Our findings are particularly relevant for neurodegenerative disorders such as Parkinson’s and Alzheimer’s,” she says.

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Anti-aging pill to turn back the clock

A DRUG that slows the ageing process and prevents cancer, heart disease and Alzheimer’s, could be on sale within five years, scientists claim.

The drug is made up of chemicals that mimic resveratrol, a compound found in the skins of red grapes.

Previous research has shown resveratrol reduces the impact of a high-fat diet, doubles stamina and extends the lifespan of mice.

Sirtris Pharmaceuticals has developed a pill based on two chemicals that act in the same way and the first human clinical trials have begun.

“The excitement here is that we’re not talking about red wine any more. We’re talking about real drugs,” Sirtris co-founder David Sinclair said.

“We will make a drug to treat one disease but it will, as an added bonus, protect you against most of the other diseases of the Western world.”

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Sounds good. Sign me up!

Anti Aging Enzymes In Your Drinking Water

Within about 10 years, you might be drinking anti-aging enzymes with your bottled water. California biochemists have a plan to keep the world younger and healthier by using nanotech to deliver an enzyme called CoQ10 to our drinking water. This coenzyme is naturally produced by the body, but in smaller and smaller amounts as we age. And yet it’s vital for the body’s basic functioning, as it helps our cells convert sugars to energy. Perhaps if we boost its presence in our bodies as we age, our organs will remain productive and healthy for much longer.

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Making people healthier and younger, without them knowing about it.

How clever. 😉

We can only hope that bionanotech will eventually also increase the nutritional value of our daily foods.

I eagerly await the day where cheap meat, mass-cloned from vat, contains nothing but healthy fats, carbs and proteins.

Hoping Two Drugs Carry a Side Effect: Longer Life

Sirtris has two drugs in clinical trials. One is being tested against Type 2 diabetes, one of the many diseases of aging that the company’s scientists hope the drugs will avert. With success against just one such disease, the impact on health “could be possibly transformational,” said Dr. Patrick Vallance, head of drug discovery at GlaxoSmithKline.

The new drugs are called sirtuin activators, meaning that they activate an enzyme called sirtuin. The basic theory is that all or most species have an ancient strategy for riding out famines: switch resources from reproduction to tissue maintenance. A healthy diet but with 30 percent fewer calories than usual triggers this reaction in mice and is the one intervention that reliably increases their life span. The mice seem to live longer because they are somehow protected from the usual diseases that kill them.

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Could this be the beginning of a massive tidlewave?

Will life extension follow the same path as solar is doing right now?

Life Extension From Caloric Restriction… In A Pill!

In 2006, Sinclair and National Institute on Aging gerontologist Rafael de Cabo, also a co-author of the Cell Metabolism study, used resveratrol to improve the health and extend the lives of obese mice on high-calorie diets. The latest study involved both obese and normal mice, fed standard, low- and high-calorie fare.

Regardless of mouse weight and diet, resveratrol worked wonders. At two years of age, or the mouse equivalent of senescence, the mice were more coordinated than their non-dosed counterparts. Their bones were thicker and stronger, their eyes free of cataracts, their hearts beating strong. At the cellular level, tissues displayed gene-level changes almost identical to those produced by caloric restriction.

The mitochondria of resveratrol-taking mice also proved healthy. Mitochondrial degeneration has been implicated in a variety of diseases, leading some researchers to believe that heart disease, cancer and dementia — all the so-called diseases of aging — have a common root.

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I can’t believe what’s possible in mice these days.

I’ve seen’em heal from spinal paralysis, get a cure for sickle cell anemia, and more. And now they’re getting longer and healthier life in which they’re allowed to eat all they want.

Makes me wish I was one of them.

Double Your Lifespan with a Drug that Mutates Your Ribosomes

Double Your Lifespan with a Drug that Mutates Your Ribosomes

It’s been known for a while that restricting your diet will increase your lifespan, but now researchers have shown one reason why: Eating less causes your ribosomes (your cells’ protein factories) to mutate. And it’s looking like mutated ribosomes (pictured here) could be one key to life extension. The good news is that you may not have to starve yourself to mutate your ribosomes anymore. Biologists at the University of Washington have managed to induce the life-extending mutation in ribosomes with a drug that doubles the lifespan of yeast cells.

Geneticists Discover a Way to Extend Lifespans to 800 Years

Geneticists Discover a Way to Extend Lifespans to 800 Years

yeast.jpg

There is now a way to extend the lifespan of organisms so that humans could conceivably live to be 800 years old. In an amazing development, scientists at the University of Southern California have announced that they’ve extended the lifespan of yeast bacteria tenfold — and the recipe they used to do it might easily translate into humans. It involves tinkering with two genes, and cutting down your calorie intake. Tests have already started on people in Ecuador.